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Mechanism of Leptin Leptin originates in fat cells and circulates at levels proportionate to body fat. Leptin talks directly to the hypothalamus gland of the brain. When leptin levels are high in the properly functioning person, it tells the brain to decrease food intake and increase sympathetic nerve activity, thus increasing metabolic rate.5 Leptin is a hormone that is secreted in white adipose tissue. Leptin was found to signal the brain, having a primary influence on body weight, involved with insulin, cardiovascular health, reproductive function, sex hormones, immune function, adrenal function, stress, thyroid function, bone health, cancer and inflammation.6 Because its receptors respond to sweetness, it affects sugar cravings in a way that, when rewarded, fosters a “learned addiction.”7 Excess eating, in turn, raises the blood’s level of triglycerides, which can impede leptin from reaching the brain.8 So the body is tricked into thinking it’s starving. The overeating that typically ensues then clogs the fat cells even more, signaling the liver to create extra cholesterol.9 The result is that with overeating, the hormone’s receptors become less sensitive--a syndrome known as “leptin resistance.”8 The hypothalamus, functioning much like a thermostat, gets continually dialed up in a way that further increases appetite. Overeating begets more overeating. Leptin miscues are one reason we can gorge on a heavy meal, capped off with dessert, and not feel uncomfortably full until the regretful ride home, half an hour later. Like a crackerjack cleaning crew, bauhinia essentially scrubs and tidies up the leptin receptors, enabling them to work with brisk efficiency at fostering a sense of satisfaction to foil phony hunger pangs. The hormonal signals reach the brain with greater alacrity, so metabolism, regulated by the hypothalamus, returns to healthy function. Suddenly, that second slice of pizza doesn’t beckon so irresistibly. Further research confirms this response. Earlier this year, we conducted a placebo-controlled, double-blinded study. It started as a four-week program10, involving 31 patients (18 male, 13 female) and was extended to an eight-week study of eight subjects (three male, five female) from the treatment group.11 In the initial pilot program, subjects were randomly divided into two groups and instructed to take five milliliters of the test material--either bauhinia leaf extract or a placebo solution--half an hour before each meal. In addition to noting their weight, we measured the circumference of the chest, waist and hips, as well as body mass index and waist-to-hip ratio. The subjects were ordered not to alter their diet and exercise regimens in any way. Directions: Take 1 or 2 gelcaps three times daily. Preferably (1) hour before each meal. For higher dosage, consult your health care practitioner. Ingredients: Extract of Bauhinia, Essential oils. Packaging: 90 gel capsules per bottle. |
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